The data indicated that several DEGs, including prostaglandin I2 (prostacyclin) synthase (PTGIS), RGS5, selectin E (SELE), endothelin converting enzyme (ECE), and ATPase, Na+/K+ transporting, and beta 1 polypeptide (ATP1B1), were highly associated with hypertensive disease (Fig. 2D–G and Table 2). This evidence concerns the gene ECE1 and hypertensive disorder.