For example, GSDMB silencing resulted in significant changes in the expression of flow central HIVEP1 (expression increased), MAPK8 (decreased), IL27RA (increased), and the COPD seed gene IL27 (increased), while GSDMB overexpression resulted in changes in expression opposite to those induced by GSDMB silencing (MAPK8 increased, IL27RA decreased, with non-significant decreased expression of HIVEP1, see path 1 in Fig. 6b. Here, GSDMB is linked to chronic obstructive pulmonary disease.