We found strong evidence for connections between the asthma seed GSDMB and its predicted downstream target COPD seeds IL27, HHIP, and GSTCD. As summarized in Fig. 6b, both overexpression and silencing of GSMDB resulted in reciprocal downstream alterations in the expression of most flow central genes and target COPD genes. The gene discussed is HHIP; the disease is chronic obstructive pulmonary disease.