GSDMB is expressed in bronchial epithelium (a cell type relevant to the pathogenesis of both asthma and COPD) and recent murine models suggest that GSDMB overexpression results in spontaneous airway remodeling64—subepithelial fibrosis—that in humans contributes to fixed airway obstruction observed in COPD. This evidence concerns the gene GSDMB and chronic obstructive pulmonary disease.