Other studies also reported an age-related increase of plasma NfL; one study included 193 cognitively healthy controls, 197 patients with a mild cognitive impairment and 180 patients with Alzheimer’s disease15 and another one included 41 nondemented controls, 25 patients with a mild cognitive impairment and 33 patients with Alzheimer’s disease16. The gene discussed is NEFL; the disease is Cognitive impairment.