In the cognitively unimpaired control group, the rate of change in plasma NfL from baseline was lower (2.4 pg mL−1 per year) compared to MCI (2.7 pg mL−1 per year) and AD (4.9 pg mL−1 per year) and could further be related to imaging variables, including lower FDG-PET and increased atrophy measures22. This evidence concerns the gene NEFL and Alzheimer disease.