The observed increase of p-H3S10 after MSK1 overexpression in AGS cells, and the decrease of p-H3S10 after H89-mediated MSK1 inhibition in AGS and MKN45 cell lines confirmed MSK1-controlled phosphorylation of H3S10 in GC cells (Fig. 2h and Supplementary Fig. 2g). The gene discussed is RPS6KA5; the disease is gastric cancer.