As expected, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that “pathways in cancer” is one of the most significantly altered gene set concepts in NOC-transformed cells, and gene set enrichment analysis (GSEA) revealed a large fraction of IL6/STAT3 downstream genes that displayed significant alterations (Supplementary Fig. 4a, b). The gene discussed is IL6; the disease is cancer.