CRHR1 and Anxiety: Corticotropin-releasing factor (CRF) and the CRF receptor-1 (CRF1) are expressed throughout the amygdala (Van Pett et al., 2000; Calakos et al., 2017) and have been implicated in neuroplastic changes related to fear (Hubbard et al., 2007), anxiety (Overstreet et al., 2004; Rainnie et al., 2004), and alcohol exposure (Nie et al., 2004; Roberto et al., 2010; Herman et al., 2013; Lovinger and Roberto, 2013).