GBZ (100 μm) also produced a reduction in the amplitude of the holding current or rms noise that was not significantly different between CRF1+ neurons from AIR, CIE, and CIE-WD mice (10.3 ± 0.5–8.8 ± 0.6, 9.6 ± 0.7–8.3 ± 0.5, and 9.3 ± 0.7–8.5 ± 0.9 pA; p = 0.4238 by one-way ANOVA; n = 5–7 cells from 3–4 mice/group]. This evidence concerns the gene CRHR1 and Wilson disease.