IGFBPL1 and metastatic malignant neoplasm in the lymph nodes: Methylation of IGFBPL1 was significantly associated with TNM stage (p = 0.012) and tumor size (p = 0.009) (Table 1), whereas it was not associated with age, gender, lymph node metastasis, tumor cell differentiation, cancer embolus, distal metastasis, smoking, alcohol consumption, or family history (all p > 0.05).