TNF and chronic granulomatous disease: Henriet et al., conducting an in vivo study with Aspergillus fumigatus and Aspergillus nidulans, demonstrated that chloroquine may increase the antifungal activity of leucocytes isolated in those with chronic granulomatous disease (CGD) at a low concentration through regulating the production of interleukin-1β and tumor necrosis factor-α [16].