This choice is supported by the following considerations: 1) even though we and others reported muscle damage in cancer cachexia, muscle regeneration is severely hampered in this condition [20,54,57]; therefore the occurrence of central nuclei due to myofiber neoformation or repair following damage is unlikely; 2) the kinetics of myofiber regeneration is not compatible with our observations of displaced nuclei existing in the absence of perinatal myosins. The gene discussed is MYH14; the disease is cancer.