IFNG and neoplasm: Even a single parenterally supplied Th1 cytokine (IFN-γ) showed substantial increased activity in combination with simvastatin in the mouse model (Figure 8F), consistent with the notion that Th1 cytokines are major effector mechanisms of DC immunotherapy induced responses in this model, and furthermore suggesting a non-cell-based immunotherapy (i.e., a recombinant cytokine) that can be used in combination with simvastatin to achieve an anti-tumor effect.