CXCL12 and neoplasm: Additionally, CD4+TIM3+ TILs also upregulated tumor metastasis-related genes, including MMP16, EPHA7, TSPAN3, CDCA2, WISP1, CXCL12, GPX3, ATF3, PTPRB, and EC1 (Figure 5B, bottom heat map, p value < 0.01).