HAVCR2 and neoplasm: Interestingly, we found that signals involved in tumor migration and metastasis, including development of epithelial cells (6%), cell spreading of leukocytes (3%), activation of leukocytes (27%), activation of lymphocytes (17%), activation of T lymphocytes (13%), activation of mononuclear leukocytes (19%), and lymphopoiesis (15%) were upregulated with a Z-score of >1.45 in TIM-3+, compared with TIM-3− cells (Figure 3G).