CD8A and colorectal carcinoma: This expression pattern was also observed on CD8+ T cells as TIM-3 was highly upregulated on CD8+ TILs compared to NILs and PBMC from CRC patients (22.2% ± 3.0% vs. 13.2% ± 1.3% vs. 1.8% ± 0.3%, Figure 1C).