Genes including calcium-calmodulin signaling (ASPH, CHDH, PRRG4, TLL1, and CABYR), vesicle transport (GOLGA6A, STRIP1, COG8, and SNF8), signal transduction (TNFSF4, IRF2, KCNA1, NANOG, KL, RAG1, KSR2, MPZL1, SCIMP, ZNF821, RAPGEFL1, and STAT5B), cell migration (PLAT, RLTPR, TPTEP1, SNX5, CHST3, PRKCE, CRMP1, and SYNE3) and tumor metastasis (MMP16, EPHA7, TSPAN3, CDCA2, WISP1, CXCL12, GPX3, ATF3, PTPRB, and ENC1) were significantly upregulated in TIM-3+, compared with CD25+ T cells (Figure 5B,H, p value < 0.01). The gene discussed is RAPGEFL1; the disease is neoplasm.