Next, we found that genes related to cell migration including ACTR3, CCR7, ITGAE, PIK3CA, CRC, SRC, WIPF1, RDX, RHO, ROCK1, and MAPK1 [28] were upregulated in CD4+TIM3+ TILs (Figure 5B, bottom heat map). This evidence concerns the gene ACTR3 and colorectal carcinoma.