CASP8 and breast carcinoma: In the Tor et al. [29] studies, apoptosis was effectively induced by putting MCF-7 cells to oxidative stress via the ethyl acetate extract of D. suffruticosa. In the Pilco-Ferreto and Calaf [30] study, authors indicated that doxorubicin induced apoptosis by upregulating Bax, caspase-8 and caspase-3, and by the downregulation of Bcl-2 protein expression in MCF-10F, MCF-7 and MDA-MB-231 breast cancer cells.