E2F1 and Alzheimer disease: TF-association has also been used by Rahman et al. in a network-based method to profile gene expression of DEGs associated with AD; they identified a number of AD-associated TFs, including JUN, YY1, E2F1, FOXC1, GATA2, SRF, USF2, PPARG, FOXL1, and NFIC [87], consistent with the present study.