The most important up-regulated overlapping genes are as follows: (a) FLI1, PACSIN2, BICD1, TCP11L2, and ENTPD1 among T2D, ED, and MS, (b) PEG10 and EFCAB14 among T2D, PD, and MS, (c) ITGB8 among T2D, HD, PD, and MS, (d) FBLN1 among T2D, ALS, and MS, (e) IGFBP5 among T2D, CP, and MS, (f) SGCB among T2D, HD, and MS, (g) SLC25A30 among T2D, PD, and CP. This evidence concerns the gene ITGB8 and amyotrophic lateral sclerosis.