While TGF-β is transiently expressed during skeletal muscle regeneration following injury [10], prolonged elevated TGF-β protein levels are associated with pathologies such as DMD [3], limb girdle muscular dystrophy and amyotrophic lateral sclerosis (ALS), as well as sarcopenia [11,12,13]. This evidence concerns the gene TGFB1 and amyotrophic lateral sclerosis.