Celastrol was demonstrated to decrease interlukein-6 (IL-6) secretion and gene expression via downregulation of NF-κB in prostate carcinoma PC-3 cells [42], and inhibit colorectal cancer cell growth and migration through the suppression of tumor necrosis factor alpha (TNF-α) expression and IL-1b protein [43]. The gene discussed is TNF; the disease is colorectal cancer.