GPC3 and hepatocellular carcinoma: Recently, Liu et al. described a one-vector system for inducible cytokine expression driven by an NFAT promoter element with six NFAT response elements that is activated following activation of a constitutively expressed Glypican-3 (GP3)-CAR, and they nicely demonstrated the functionality of their one-vector system in in vivo mouse models for hepatocellular carcinoma (HCC) [21].