ITIH4 and AIDS: In this work we described the immunosuppressive function of MVA A40R gene and tested its role on antigen-specific immune responses in vivo after deleting the MVA A40R gene in the vector backbone of MVA-B, an HIV/AIDS vaccine candidate that expresses HIV-1IIIB GPN as an intracellular polyprotein and HIV-1BX08 gp120 as a cell-released product from HIV-1 clade B isolate [16].