CD4 and AIDS: Even if definitive conclusions on management of APL in PLWH cannot be drawn, due to the limited number of patients so far described, standard ATRA-based APL therapy combined with ART, preferably including integrase inhibitors in order to reduce potential drug-drug interactions, may be suggested, especially in fit subjects with adequate performance status and well controlled HIV infection, with CD4+ T cell count > 200/μL and absence of history of AIDS-related complications [65,66].