On the other hand, genes negatively correlated with HOTAIR (Pearson score < −0.3 and p-value < 0.05) were enriched in terms of metabolic/catabolic processes, mRNA processing, cell cycle, response to stress, autophagy, IGF-1 Signaling Pathway, Prostate cancer, HIF-1 signaling pathway, Estrogen signaling pathway (enrichment p-value < 0.05, data not shown). Here, IGF1 is linked to Familial prostate cancer.