Interestingly, miR-31-5p was the miRNA showing the most negative correlation with AR (Pearson score −0.43 and p-value = 0.0026) and concomitant positive correlation with ESR1 (Pearson score 0.49 and p-value = 0.0004) in our cohort of prostate cancer tissues. Here, ESR1 is linked to Familial prostate cancer.