In the last two samples of this transdifferentaition process (LTL331_Cx_relapsed and LTL331R), classified as neuroendocrine by the authors, ESR1 expression levels increased if compared to the remaining 12 adenocarcinomas (logFC = 1.14 and Adj.P.Val = 1.14 × 10−6), with a positive correlation with CHGA and a negative correlation with AR (Figure 4A–D). The gene discussed is ESR1; the disease is adenocarcinoma.