IL1B and rheumatoid arthritis: Pyroptosis pathway: Extracellular acidosis, which accompanies joint inflammation of RA, significantly increases the expression of acid-sensing ion channel 1a (ASIC1a), IL-1β, IL-18, apoptosis-associated speck-like protein (ASC), neuronal apoptosis inhibitor protein, class 2 transcription activator, of the major histocomplex, heterokaryon incompatibility and telomerase-associated protein 1 (NACHT), leucine-rich repeat (LRR) and PYRIN domain (PYD) domains-containing protein 3 (NLRP3) and caspase-1 and mediates chondrocyte pyroptosis [75,76].