e) Lymphotoxin α: IL-1β induces lymphotoxin α and enhances adhesiveness of T lymphocytes to chondrocytes [53], and lymphotoxin α stimulates the proliferation of RA synovial fibroblasts, and secretion of cytokines and metalloproteinases from synovial fibroblasts [54]. The gene discussed is IL1B; the disease is rheumatoid arthritis.