PTGS2 and colorectal carcinoma: S. gallolyticus can accelerate the development of CRC, and Abdulamir et al. found that S. gallolyticus may aggravate the tumor microenvironment through inflammatory factors such as cyclooxygenase-2 (COX-2), IL-1 and IL-8, followed by accelerated CRC development (Figure 1g) [103].