For example, Israel et al. generated iPSCs from Sporadic Alzheimer’s disease patients, demonstrating that they have high levels of Amyloid-β and Tau protein hyperphosphorylation and that they represent a suitable model to study the correlation of phosphorylation of Tau, activation of GSK-3β and the processing of APP by the activity of β-secretase [39]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.