Additional abbreviations: BMP, bone morphogenetic protein; CP, ceruloplasmin; EPO, erythropoietin; ERFE, erythroferrone; Fe, iron; FeTf, iron loaded transferrin; HAMP, hepcidin antimicrobial peptide; Hb, haemoglobin; HFE, human hemochromatosis gene; HGF, hepatocyte growth factor; HMOX 1, heme oxygenase 1; HP, haptoglobin; Hpx, hemopexin; HRG1, haem transporter 1; IL6, interleukin 6; LIP, labile iron pool; NTBI, non-transferrin bound iron; O2, oxygen; PDGF, platelet-derived growth factor; TNF, tumor necrosis factor; ZIP14, solute carrier family 39 zinc transporter. The gene discussed is ERFE; the disease is hemochromatosis type 1.