Nevertheless, RyR1-Q3970 and RyR2-Q3925 are very important residues, since RyR1-Q3970K causes central core disease (Snoeck et al. 2015) and RyR2-Q3925E is associated with arrhythmogenic syndrome (Medeiros-Domingo et al. 2009). The gene discussed is RYR2; the disease is Central core disease.