This process continued at 7- and 14-days post inoculation including round globular inclusions (Fig. 1B, Day 3 panel) and skein-like inclusions (Fig. 1B, Day 14 panel) that are morphologically representative of TDP-43 inclusions observed in ALS post-mortem tissue (Fig. 1B). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.