ERBB2 and breast carcinoma: In HER2/neu negative breast cancer cells, overexpression of MEK1/2-ERK1/2 pathway activators, H-Ras (G12V) and ID-1, also significantly increased the levels of miR-21 so miR-21 expression could be affected by the MEK1/2-ERK1/2 pathway activators independent of HER2 expression [24].