Despite the NF-κB-regulated acute inflammatory response is important to effectively combat the infectious bacteria causing mastitis, it is important that the inflammatory process is rapidly attenuated because prolonged production of ROS, cytokines and other inflammatory molecules causes structural damage of the mammary gland through injurious action on cellular components (lipids, proteins, DNA), thereby, decreasing cell viability, and ultimately inducing cell death [14]. Here, NFKB1 is linked to mastitis.