ADRB2 and gastric cancer: Supplementary Figure 3A, 3B shows different gene and pathway analyses in blood-isolated Tregs. Great effort has been devoted to identifying genes that can serve as to monitor GC prognosis. Our results showed that KDM5D and ADRB2 in blood-isolated Tregs was upregulated in peripheral blood of GC patients compared to controls and that high expression of KDM5D and ADRB2 correlated with poor prognosis (Supplementary Figure 3C, 3D).