BAX and neoplasm: In addition, miR-15b has been repeatedly demonstrated to target important BCL-2 family proteins, including both anti-apoptotic (e.g., Bcl-2) and pro-apoptotic (e.g., Bax) members and regulate the expression of caspases 3, 7, 8, or 9, as well as participate in tumorigenesis and tumor development by enhancing or inhibiting cell activity, proliferation and apoptosis [50–55].