For example, the activation of C-fibers by injecting capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, or mustard oil, a TRP ankyrin 1 (TRPA1) agonist, into the skin with neurogenic inflammation over the median nerve blocks the development of hypertension in rats [9]. The gene discussed is TRPA1; the disease is hypertensive disorder.