Butyrate is the main source of energy for intestinal epithelial cells, which lays the foundation for a modern symbiosis theory between the gut microbiota and intestinal epithelial cells.48 It can inhibit the development of CRC and promote intestinal health through various mechanisms.70, 71 Here, we found the effects on m6A modification and expression of m6A ‘writers’ METTL3 may be involved in CRC cell proliferation affected by butyrate. This evidence concerns the gene METTL3 and colorectal carcinoma.