METTL3 and cancer: Though the underlying mechanisms of butyrate's anticarcinogenic function have not yet been elucidated, it could promote histones acetylation50, 72and the accessibility of transcription factors to nucleosomal DNA.45, 73, 74 Interestingly, cancer cells appear to be more sensitive to the actions of HDACi than nontransformed cells, but the mechanistic basis for this apparent selectivity is poorly understood.75 Butyrate participates in the m6A modification and METTL3 expression may be conducted by one or more pathway mentioned above.