METTL3 and neoplasm: For example, METTL3 was identified as an essential oncogene to promote cell cycles and growth in acute myeloid leukaemia by targeting transcription factor SP1.29 METTL3 acted as a tumour suppressor in renal cell carcinoma cells to regulate cell cycle arrest in G1 phase by targeting PI3K/Akt/mTOR signalling pathway.34