To investigate the potential mechanism of CRC cells proliferation regulated by METTL3, we used Western blot and qRT‐PCR to investigate the expression of cell cycle‐related proteins, cyclin D1, cyclin E1, CDK2, CDK4 and CDK6 by the knockdown or overexpression of METTL3. The gene discussed is CCNE1; the disease is colorectal carcinoma.