Firstly, qRT‐PCR analysis of 32 paired CRC tissues and, Western blot analysis of eight paired CRC tissues and TCGA database analysis demonstrated that METTL3 was dramatically up‐regulated in CRC tissues, compared with the paired adjacent tissues both in mRNA and protein levels (Figure 1A,B and Figure S1A). The gene discussed is METTL3; the disease is colorectal carcinoma.