In our study, TC and FPG levels were both significantly relevant to methylation of cg19693031, which was coincident to the previous study.25, 26, 42, 43 Specifically, studies suggested that DNA methylation could be altered by dyslipidemia and the stimulation of insulin or glucose.44, 45 For example, insulin could lead to changed DNA methylation in the 3′ UTR of ATP2A3. Here, INS is linked to metabolic syndrome.