CD4 and systemic lupus erythematosus: Moreover, studies suggested microRNAs were involved in the regulation of DNA methylation.47 For example, miR‐126, miR‐148a and miR‐21 could regulate methylation of CD4+ T cells and contribute to systemic lupus erythematosus.48, 49 Thus, there also might be potential microRNAs involved in the modulation of cg19693031.