TXNIP and myocardial infarction: For example, dysregulated cystathionine γ‐lyase induced by DNA methylation could contribute to the monocyte‐induced inflammation and AS.40 Hypomethylation of long interspersed nuclear element‐1 was relevant to myocardial infarction risk.41 In this work, we found that methylation of cg19693031 was decreased in the PBLs of CAD and negatively associated with increased TXNIP expression, which was further verified in THP‐1 cells.