Overexpression of HMGB1 occurs in a variety of human cancers, such as prostate cancer,32 RCC,33 hepatocellular carcinoma,34 lung cancer,35 colorectal cancer,36 and gastric cancer,37 which may suggest a potential oncogenic role of HMGB1. This finding may mean that low expression of HMGB1 is correlated with good prognosis in various cancers. This evidence concerns the gene HMGB1 and Familial prostate cancer.