Overexpression of HMGB1 occurs in a variety of human cancers, such as prostate cancer,32 RCC,33 hepatocellular carcinoma,34 lung cancer,35 colorectal cancer,36 and gastric cancer,37 which may suggest a potential oncogenic role of HMGB1. This finding may mean that low expression of HMGB1 is correlated with good prognosis in various cancers. The gene discussed is HMGB1; the disease is renal cell carcinoma.