Its role in the heart has been reevaluated in the light of the fact that Parkin deficiency at baseline did not induce cardiac dysfunction; however, Parkin is required for cardioprotection by ischemic preconditioning or statin administration (5, 6) and we previously reported that diet-induced obesity increases ischemic injury (7). Here, PRKN is linked to obesity due to melanocortin 4 receptor deficiency.