In addition to hematological findings, according to the literature, up to 10% of β-thal patients (1) exhibit clinical manifestation similar to those observed in Pseudoxanthoma elasticum (PXE) (OMIM 264800), a rare genetic disease in which ABCC6 gene mutations cause the mineralization of elastic fibers responsible for skin, ocular, and cardiovascular complications that generally start after puberty and continuously progress with age (2). This evidence concerns the gene ABCC6 and pseudoxanthoma elasticum (inherited or acquired).