However, in the recent years, the expanding knowledge on the mechanisms controlling the mineralization process has revealed that, in addition to ABCC6, several other genes can be responsible for ectopic mineralization phenotypes (2), but, to our knowledge, a multigene approach has not been applied to patients in which beta-thalassemia is associated with PXE-like connective tissue manifestation. The gene discussed is ABCC6; the disease is Pseudoxanthoma elasticum.