TENT2 and neoplasm: These findings suggest two conclusions: (1) MPK-1 is critical for the formation of gld-2(+/−) gld-1(+/−); puf-8(−/−) germline tumors at 25°C, and (2) the mechanisms of gld-2(−/−) gld-1(−/−); puf-8(−/−) and gld-2(+/−) gld-1(+/−); puf-8(−/−) germline tumor formation are different.