It is downregulated in the urine of patients with bladder cancer. It is downregulated in 17 types of tumor cells. binds to Dicer to recruit to the 3′-UTR of survivin mRNA, resulting in degradation of this mRNA. It is downregulated by HPV-16/18-encoded E2. It inhibits tumor growth and metastasis in the RenCa murine renal adenocarcinoma model. This evidence concerns the gene DICER1 and urinary bladder carcinoma.