Integrating these approaches is predicted to be even more powerful (Chakraborty et al., 2018; Manem et al., 2018) (Table 1) For instance, a genomic/transcriptomic/proteomic combined approach has confirmed the existence of the known molecular subtypes (LumA, LumB, HER2+, and BL) of breast cancer (Cancer Genome Atlas Network, 2012) as well as allowing identification of novel therapeutic targets in PDX models (Huang K. L. et al., 2017). The gene discussed is ERBB2; the disease is breast cancer.