Together, these studies have consistently found that the development of various kidney diseases such as crystal-related nephropathy, IgA nephropathy, and DN are associated with the activation of the NLRP3 inflammasome, which mediates inflammatory responses through the NLRP3/CAS1/IL-1β/IL-18 axis and participates in the early stage of renal fibrosis. This evidence concerns the gene IL18 and renal fibrosis.