AKT1 and cancer: Given the central role of PI(3,4,5)P3 in human cancer, it is not surprising that inhibition of PI(3,4,5)P3 production and/or its downstream effectors utilizing kinase inhibitors to PI3K, AKT, or mTOR (mechanistic target of rapamycin) have been utilized as promising strategies for cancer therapy (Engelman, 2009).