STAR and cancer: In this review, we discuss the role of several LTPs, including phosphatidylinositol (PI)-transfer proteins (PITPs) and steroidogenic acute regulatory protein (StAR)-related lipid transfer (START family) (Soccio and Breslow, 2003; Alpy and Tomasetto, 2005) in human cancer, and further describe the heterogeneity of MCSs, their function in lipid transport and calcium signaling, and their implication in cancer biology.