CREB3L1 and breast carcinoma: In the mesenchymal subtype of TNBC, PERK signaling enhanced invasion and metastasis through interaction with the transcription factor CREB3L1 (cAMP responsive element binding protein 3 like 1) (Feng et al., 2017), and its knockdown inhibited growth of breast carcinoma in animal models by limiting redox homeostasis (Bobrovnikova-Marjon et al., 2010).