Whatever the diagnosis, HSCT from a healthy matched sibling donor (MSD) remains the gold standard that offers the best results and allows to consider HSCT early in the course of the disease, even pre-emptively if poor outcome is predictable (38) [see reviews on Hematopoietic stem cell transplantation for WAS and DOCK8 deficiency (26) and for MHC class II expression deficiency]. Here, DOCK8 is linked to hyperinsulinemic hypoglycemia, familial, 4.