To elucidate the mechanism of the up-regulation of HCAR2 expression induced by ZIKV infection, we analyzed the transcription factor binding sites on the promoter region of HCAR2 with the online bioinformatics software (http://alggen.lsi.upc.es/cgi-bin/promo_v3/promo/promoinit.cgi?dirDB=TF_8.3). This evidence concerns the gene HCAR2 and Zika virus infectious disease.