HCAR2 and Zika virus infectious disease: As shown in Figure 1B, ZIKV infection up-regulated the expression of HCAR2 in a time-dependent manner and the highest fold change was around 27 at 48 h p.i. As ZIKV infection is associated with severe neurological diseases (Pierson and Diamond, 2018), we detected the relationship between HCAR2 and ZIKV in human glioblastoma SNB19 cells.