IFNG and infection: We measured cytokine production by cells from FPs of L. major infected mice restimulated with SLA, and found that IFN-γ production was significantly reduced in CD11ccreIL-4Rα−/lox mice compared to littermate controls, whilst IL-4 production was dramatically increased, demonstrating a switch toward Th2-type responses at the site of infection (Figures 6A,B).