Myeloid-derived DCs are a migratory subset of conventional DCs, known to take up antigen at the infection site and migrate to the draining LN for presentation to antigen-specific T cells, with two major subsets being CD103+ migratory tissue DCs and CD11b+ DCs (Pulendran et al., 1997; Steinman and Inaba, 1999; Martinez-Lopez et al., 2015; Mayer et al., 2017). The gene discussed is ITGAM; the disease is infection.