Compared to the high-risk individuals, the sera antibodies titers in RA patients were 1.8-fold higher for ACPA (median level 320.3 vs. 173.4 U/ml) and 6-fold higher for IgM-RF (median level 281.4 vs. 47.1 IU/ml), respectively. The gene discussed is PRTN3; the disease is rheumatoid arthritis.