To further investigate whether the observed changes in saliva microbiota was associated with the autoimmune characteristics in high-risk individuals and with other disease parameters in RA, we analyzed the correlations of the relative abundance of bacterial genera with (1) serum concentrations of ACPA and RF in high-risk and RA individuals, (2) disease activity parameters including CRP, ESR, DAS28, and (3) course of the disease in RA patients. The gene discussed is CRP; the disease is rheumatoid arthritis.