We found 30 genes enriched in the PI3K-Akt signaling pathway, 21 genes in the Rap1 signaling pathway, 16 genes in the mTOR signaling pathway, 16 genes in the JAK-STAT signaling pathway, 23 genes in regulation of actin cytoskeleton, 16 genes in the relaxin signaling pathway, 18 genes in focal adhesion, 22 genes in human cytomegalovirus infection, 16 genes in hepatitis C, and 16 genes in hepatitis B. These results indicate that the identified HDFs are important for infectious diseases and cytoskeleton reorganization. Here, MTOR is linked to hepatitis B virus infection.