There were many familiar pathways that were closely connected with bone derived sarcoma formation, such as soft tissue sarcoma, osteoclast differentiation, apoptosis process, cell cycle, cell adhesion, etc. Wnt signaling pathway and MAPK1/MAPK3 signaling pathway have been widely reported in previous studies regarding OSA. The gene discussed is MAPK1; the disease is obstructive sleep apnea syndrome.