MGMT and glioblastoma: As regards the PFS, patients who underwent a GTR and were MGMT methylated did not show a better outcome if compared with patients carrying MGMT unmethylated GBM (methylated = 9 months, unmethylated = 7 months, Log-rank p = 0.256; U: HR = 1.3215, 95%CI: 0.8134, 2.147) (Figure 3D).