TNF and cancer: Exhausted CD8+ T cells are characterized by high levels of inhibitory receptors (PD-1/CTLA-4/TIM-3/LAG-3//BTLA/TIGIT) and production of fewer effector cytokines (IL-2/IFNγ/TNF/GzmB) that lead a diminished ability to eliminate cancer cells and their final deletion in the TME (207, 208).