Galunisertib (LY2157299), a small molecule antagonist of TGFβ-R1 is being studied in combination with an anti-PD-L1 in NSCLC, hepatocellular carcinoma, pancreatic cancer (NCT02423343, NCT02734160) and with paclitaxel in triple negative breast cancer (NCT02672475). The gene discussed is CD274; the disease is non-small cell lung carcinoma.