In agreement with tumor growth inhibition, immunohistochemistry showed significant reduction of Ki67+ cells (Figure 8C) and a higher number of cleaved-caspase 3+ (Figure 8D), as well as acetyl-H3+ (Figure 8E) and acetyl-α tubulin+ (Figure 8F) cells, in the tumors from mice treated with ST8176AA1 compared to either vehicle or trastuzumab. This evidence concerns the gene CASP3 and neoplasm.