Our model exhibited a powerful ability to identify HCC in cirrhotic patients with AFP < 400 μg/L, with an AUROC of 0.875, sensitivity of 73.5%, specificity of 89.1%, and accuracy of 83.0%; more than 10% of diagnostic accuracy was obtained by the model compared with AFP, indicating that the conventional clinical indicators remarkably enhanced the ability of AFP to identify HCC. The gene discussed is AFP; the disease is hepatocellular carcinoma.