Our model had an AUROC of 0.918 for the diagnosis of HCC, which is better than or comparable to that for well-known serum HCC biomarkers alone and in combination with AFP, as shown in a meta-analysis (18), in which the summary ROCs were 0.79 and 0.87 for DCP, respectively, 0.71 and 0.83 for AFP-L3, respectively, 0.76 and 0.85 for glypican-3 (GPC3), respectively, and 0.91 and 0.93 for Golgi protein 73 (GP73), respectively. This evidence concerns the gene AFP and hepatocellular carcinoma.